The Codon Usage to Specific Tissue OptiMizer (CUSTOM) provides a codon optimization tool for tissue-specific gene design.

This web server provides a graphical frontend to the original Python package. Please check the documentation for more advanced features.

For a description of the method, refer to the original manuscript: Hernandez-Alias et al. (2023).

New Job
Select the target tissue:
Number of iterations to generate a pool of optimized sequences:
10 1000

Select the best sequences based on: